UEFA confirmed the draw in a live event held on Friday afternoon.
36 Lion product Peter Olayinka and his Slavia Praha team will face Rangers for a place in the final eight.
On the books of Rangers are the Nigerian trio of Joe Aribo, Leon Balogun and Calvin Bassey.
Shola Shoretire should get some minutes when Manchester United face AC Milan over two legs.
Iyayi Believe Atiemwen will be hoping to help Dinamo Zagreb eliminate Tottenham Hotspur.
Meanwhile, Samuel Chukwueze’s Villarreal will fancy their chances of eliminating Dynamo Kyiv.
Manchester United vs AC Milan
Olympiakos vs Arsenal
Dinamo Zagreb vs Tottenham
Slavia Prague vs Rangers
Ajax vs Young Boys
Roma vs Shakhtar
Dynamo Kyiv vsVillarreal
Granada vs Molde
Meanwhile, UEFA will confirm the match dates and Covid-affected venues in due course.